DSG2 [The Human Chemical-Genetic Interaction Map Project]

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======= DSG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSG2
  * **<color #00a2e8>Official Name</color>**: desmoglein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1829|1829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14126|Q14126]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Purkinje myocyte development|
|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|
|His-Purkinje system development|
|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|
|cardiac muscle cell-cardiac muscle cell adhesion|
|desmosome organization|
|cardiac conduction system development|
|bundle of His cell to Purkinje myocyte communication|
|regulation of ventricular cardiac muscle cell action potential|
|desmosome|
|regulation of cardiac muscle cell action potential|
|heterotypic cell-cell adhesion|
|regulation of cardiac muscle cell contraction|
|regulation of heart rate by cardiac conduction|
|regulation of actin filament-based movement|
|cell communication involved in cardiac conduction|
|response to progesterone|
|intercalated disc|
|regulation of action potential|
|ventricular cardiac muscle tissue development|
|lateral plasma membrane|
|cell adhesion molecule binding|
|homotypic cell-cell adhesion|
|maternal process involved in female pregnancy|
|cornified envelope|
|regulation of cardiac muscle contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of heart rate|
|cornification|
|multicellular organismal signaling|
|cell-cell junction organization|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell-cell junction|
|female pregnancy|
|response to ketone|
|multi-multicellular organism process|
|cell junction organization|
|keratinization|
|regulation of muscle system process|
|regulation of heart contraction|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|keratinocyte differentiation|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|epidermal cell differentiation|
|apical plasma membrane|
|response to steroid hormone|
|skin development|
|regulation of actin filament-based process|
|epidermis development|
|regulation of membrane potential|
|cell-cell adhesion|
|heart development|
|cell junction|
|regulation of system process|
|cell surface|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|calcium ion binding|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to drug|
|programmed cell death|
|cell death|
|epithelium development|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.85|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSG2 Expression in NALM6 Cells: 1.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>