DSG2

Entrez Summary: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016].
UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Deferoxamine 11μM R07 exp350	1.85
A-395 10μM R05 exp218	2.02

Cadherin C
Cadherin

Purkinje myocyte development
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
His-Purkinje system development
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cardiac muscle cell-cardiac muscle cell adhesion
desmosome organization
cardiac conduction system development
bundle of His cell to Purkinje myocyte communication
regulation of ventricular cardiac muscle cell action potential
desmosome
regulation of cardiac muscle cell action potential
heterotypic cell-cell adhesion
regulation of cardiac muscle cell contraction
regulation of heart rate by cardiac conduction
regulation of actin filament-based movement
cell communication involved in cardiac conduction
response to progesterone
intercalated disc
regulation of action potential
ventricular cardiac muscle tissue development
lateral plasma membrane
cell adhesion molecule binding
homotypic cell-cell adhesion
maternal process involved in female pregnancy
cornified envelope
regulation of cardiac muscle contraction
regulation of striated muscle contraction
cardiac conduction
regulation of heart rate
cornification
multicellular organismal signaling
cell-cell junction organization
regulation of muscle contraction
cardiac muscle tissue development
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
female pregnancy
response to ketone
multi-multicellular organism process
cell junction organization