DSN1 [The Human Chemical-Genetic Interaction Map Project]

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======= DSN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSN1
  * **<color #00a2e8>Official Name</color>**: DSN1 component of MIS12 kinetochore complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79980|79980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H410|Q9H410]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mis12 component|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed nuclear chromosome inner kinetochore|
|nuclear MIS12/MIND complex|
|MIS12/MIND type complex|
|condensed chromosome kinetochore|
|azurophil granule lumen|
|mitotic sister chromatid segregation|
|spindle pole|
|fibrillar center|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|mitotic cell cycle|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|nucleolus|
|leukocyte activation|
|cell cycle process|
|secretion by cell|
|export from cell|
|chromosome organization|
|cell activation|
|immune effector process|
|secretion|
|cell cycle|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.85|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.48|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.26|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.21|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.11|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.11|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.89|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 193/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|6/28|
|bone|9/26|
|breast|14/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|4/21|
|liver|3/20|
|lung|15/75|
|lymphocyte|7/16|
|ovary|8/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSN1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>