DSN1

Entrez Summary: N/A
UniProt Summary: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 193/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	6/28
bone	9/26
breast	14/33
central nervous system	19/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	1/1
gastric	5/16
kidney	4/21
liver	3/20
lung	15/75
lymphocyte	7/16
ovary	8/26
pancreas	5/24
peripheral nervous system	4/16
plasma cell	2/15
prostate	1/1
skin	1/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	9/29
uterus	3/5

Expression Distribution

condensed nuclear chromosome inner kinetochore
nuclear MIS12/MIND complex
MIS12/MIND type complex
condensed chromosome kinetochore
azurophil granule lumen
mitotic sister chromatid segregation
spindle pole
fibrillar center
sister chromatid segregation
mitotic nuclear division
nuclear chromosome segregation
chromosome segregation
nuclear body
nuclear division
organelle fission
neutrophil degranulation
neutrophil activation involved in immune response
cell division
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
mitotic cell cycle process
leukocyte activation involved in immune response
cell activation involved in immune response
mitotic cell cycle
regulated exocytosis
leukocyte mediated immunity
exocytosis
nucleolus
leukocyte activation
cell cycle process
secretion by cell
export from cell
chromosome organization
cell activation
immune effector process