DSP [The Human Chemical-Genetic Interaction Map Project]

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======= DSP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSP
  * **<color #00a2e8>Official Name</color>**: desmoplakin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1832|1832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15924|P15924]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125647|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Plectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to adherens junction|
|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|
|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|
|cardiac muscle cell-cardiac muscle cell adhesion|
|ventricular compact myocardium morphogenesis|
|fascia adherens|
|desmosome organization|
|protein localization to cell junction|
|bundle of His cell to Purkinje myocyte communication|
|regulation of ventricular cardiac muscle cell action potential|
|intermediate filament organization|
|desmosome|
|regulation of cardiac muscle cell action potential|
|heterotypic cell-cell adhesion|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|cell communication involved in cardiac conduction|
|intercalated disc|
|ventricular cardiac muscle tissue morphogenesis|
|regulation of action potential|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|protein kinase C binding|
|ventricular cardiac muscle tissue development|
|cell adhesion molecule binding|
|homotypic cell-cell adhesion|
|scaffold protein binding|
|peptide cross-linking|
|ficolin-1-rich granule membrane|
|cornified envelope|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|regulation of cardiac muscle contraction|
|muscle tissue morphogenesis|
|adherens junction organization|
|muscle organ morphogenesis|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of heart rate|
|structural constituent of cytoskeleton|
|cornification|
|intermediate filament|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|multicellular organismal signaling|
|cell-cell junction organization|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|structural molecule activity|
|basolateral plasma membrane|
|cell junction organization|
|keratinization|
|regulation of muscle system process|
|regulation of heart contraction|
|heart morphogenesis|
|keratinocyte differentiation|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|epidermal cell differentiation|
|skin development|
|regulation of actin filament-based process|
|epidermis development|
|regulation of membrane potential|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|heart development|
|tissue morphogenesis|
|response to wounding|
|myeloid leukocyte activation|
|regulation of system process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|epithelial cell differentiation|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|circulatory system development|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell activation|
|cell death|
|immune effector process|
|cytoskeleton organization|
|epithelium development|
|secretion|
|RNA binding|
|tissue development|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSP Expression in NALM6 Cells: -2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>