DSP

Entrez Summary: This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to adherens junction
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cardiac muscle cell-cardiac muscle cell adhesion
ventricular compact myocardium morphogenesis
fascia adherens
desmosome organization
protein localization to cell junction
bundle of His cell to Purkinje myocyte communication
regulation of ventricular cardiac muscle cell action potential
intermediate filament organization
desmosome
regulation of cardiac muscle cell action potential
heterotypic cell-cell adhesion
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
regulation of actin filament-based movement
cell communication involved in cardiac conduction
intercalated disc
ventricular cardiac muscle tissue morphogenesis
regulation of action potential
intermediate filament cytoskeleton organization
intermediate filament-based process
protein kinase C binding
ventricular cardiac muscle tissue development
cell adhesion molecule binding
homotypic cell-cell adhesion
scaffold protein binding
peptide cross-linking
ficolin-1-rich granule membrane
cornified envelope
cardiac muscle tissue morphogenesis
cardiac ventricle morphogenesis
regulation of cardiac muscle contraction
muscle tissue morphogenesis
adherens junction organization
muscle organ morphogenesis
regulation of striated muscle contraction
cardiac conduction
regulation of heart rate