DUOX1

Entrez Summary: N/A
UniProt Summary: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cuticle development
hydrogen peroxide biosynthetic process
NAD(P)H oxidase activity
thyroid hormone generation
superoxide-generating NADPH oxidase activity
antibiotic biosynthetic process
NADPH oxidase complex
superoxide anion generation
thyroid hormone metabolic process
reactive oxygen species biosynthetic process
hydrogen peroxide catabolic process
peroxidase activity
NADP binding
hydrogen peroxide metabolic process
superoxide metabolic process
cell leading edge
antibiotic catabolic process
positive regulation of wound healing
cofactor catabolic process
hormone biosynthetic process
positive regulation of response to wounding
phenol-containing compound metabolic process
cellular oxidant detoxification
response to cAMP
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
response to organophosphorus
regulation of wound healing
heme binding
drug catabolic process
response to purine-containing compound
regulation of response to wounding
cellular modified amino acid metabolic process
hormone metabolic process
cofactor biosynthetic process
cellular response to toxic substance
apical plasma membrane
response to oxidative stress