DUSP10 [The Human Chemical-Genetic Interaction Map Project]

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======= DUSP10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP10
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11221|11221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6W6|Q9Y6W6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:22375048}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of epithelium regeneration|
|MAP kinase phosphatase activity|
|regulation of epithelium regeneration|
|protein tyrosine/threonine phosphatase activity|
|mitogen-activated protein kinase p38 binding|
|negative regulation of respiratory burst involved in inflammatory response|
|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|
|negative regulation of respiratory burst|
|negative regulation of p38MAPK cascade|
|regulation of respiratory burst involved in inflammatory response|
|JUN kinase binding|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|negative regulation of oligodendrocyte differentiation|
|MAP kinase tyrosine/serine/threonine phosphatase activity|
|negative regulation of JUN kinase activity|
|positive regulation of regulatory T cell differentiation|
|regulation of brown fat cell differentiation|
|peptidyl-threonine dephosphorylation|
|regulation of respiratory burst|
|negative regulation of glial cell differentiation|
|inactivation of MAPK activity|
|regulation of regulatory T cell differentiation|
|negative regulation of JNK cascade|
|regulation of oligodendrocyte differentiation|
|negative regulation of gliogenesis|
|regulation of p38MAPK cascade|
|protein tyrosine/serine/threonine phosphatase activity|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|phosphatase activity|
|negative regulation of innate immune response|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|regulation of glial cell differentiation|
|oligodendrocyte differentiation|
|negative regulation of wound healing|
|negative regulation of MAP kinase activity|
|positive regulation of T cell differentiation|
|negative regulation of response to wounding|
|regulation of JUN kinase activity|
|negative regulation of response to biotic stimulus|
|positive regulation of lymphocyte differentiation|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of developmental growth|
|regulation of gliogenesis|
|negative regulation of immune effector process|
|regulation of fat cell differentiation|
|negative regulation of epithelial cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of inflammatory response|
|regulation of wound healing|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of adaptive immune response|
|regulation of response to wounding|
|negative regulation of MAPK cascade|
|regulation of lymphocyte differentiation|
|glial cell differentiation|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|negative regulation of defense response|
|protein dephosphorylation|
|gliogenesis|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of growth|
|negative regulation of kinase activity|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|dephosphorylation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|regulation of T cell activation|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.85|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.72|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.72|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.81|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP10 Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>