DUSP10
Gene Information
- Official Symbol: DUSP10
- Official Name: dual specificity phosphatase 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 11221
- UniProt: Q9Y6W6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:22375048}.
Pfam Domains GO Terms
Pfam Domains
| Rhodanese |
| DSPc |
GO Terms
| negative regulation of epithelium regeneration |
| MAP kinase phosphatase activity |
| regulation of epithelium regeneration |
| protein tyrosine/threonine phosphatase activity |
| mitogen-activated protein kinase p38 binding |
| negative regulation of respiratory burst involved in inflammatory response |
| peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
| negative regulation of respiratory burst |
| negative regulation of p38MAPK cascade |
| regulation of respiratory burst involved in inflammatory response |
| JUN kinase binding |
| negative regulation of protein kinase activity by regulation of protein phosphorylation |
| negative regulation of oligodendrocyte differentiation |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| negative regulation of JUN kinase activity |
| positive regulation of regulatory T cell differentiation |
| regulation of brown fat cell differentiation |
| peptidyl-threonine dephosphorylation |
| regulation of respiratory burst |
| negative regulation of glial cell differentiation |
| inactivation of MAPK activity |
| regulation of regulatory T cell differentiation |
| negative regulation of JNK cascade |
| regulation of oligodendrocyte differentiation |
| negative regulation of gliogenesis |
| regulation of p38MAPK cascade |
| protein tyrosine/serine/threonine phosphatase activity |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| phosphatase activity |
| negative regulation of innate immune response |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of epithelial cell migration |
| regulation of glial cell differentiation |
| oligodendrocyte differentiation |
| negative regulation of wound healing |
| negative regulation of MAP kinase activity |
| positive regulation of T cell differentiation |
| negative regulation of response to wounding |
| regulation of JUN kinase activity |
| negative regulation of response to biotic stimulus |
| positive regulation of lymphocyte differentiation |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| negative regulation of developmental growth |
| regulation of gliogenesis |
| negative regulation of immune effector process |
| regulation of fat cell differentiation |
| negative regulation of epithelial cell proliferation |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of inflammatory response |
| regulation of wound healing |
| regulation of T cell differentiation |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| regulation of adaptive immune response |
| regulation of response to wounding |
| negative regulation of MAPK cascade |
| regulation of lymphocyte differentiation |
| glial cell differentiation |
| regulation of JNK cascade |
| positive regulation of hemopoiesis |
| positive regulation of T cell activation |
| negative regulation of defense response |
| protein dephosphorylation |
| gliogenesis |
| negative regulation of multi-organism process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of epithelial cell migration |
| negative regulation of protein kinase activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of growth |
| negative regulation of kinase activity |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| regulation of leukocyte differentiation |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| negative regulation of neurogenesis |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| dephosphorylation |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| response to lipopolysaccharide |
| regulation of T cell activation |
| negative regulation of locomotion |
| response to molecule of bacterial origin |
| regulation of developmental growth |
| negative regulation of cell development |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| negative regulation of response to external stimulus |
| regulation of cell-cell adhesion |
| nuclear speck |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| negative regulation of protein phosphorylation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| regulation of cell activation |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| Golgi apparatus |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC0649 7μM R03 exp150 | -1.85 |
| Atovaquone 15μM R08 exp451 | 1.72 |
| Nicotine 3000μM R08 exp510 | 1.72 |
| Momordin-Ic 10μM R08 exp506 | 1.81 |
| Rotenone 0.07μM R08 exp431 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10144
- Expression level (log2 read counts): 0.55
Expression Distribution
DUSP10 Expression in NALM6 Cells: 0.55
