DUSP12 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DUSP12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP12
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11266|11266]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNI6|Q9UNI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4- methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glucokinase activity|
|positive regulation of hexokinase activity|
|regulation of glucokinase activity|
|regulation of hexokinase activity|
|protein tyrosine/serine/threonine phosphatase activity|
|phosphatase activity|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of carbohydrate metabolic process|
|kinase binding|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|regulation of glucose metabolic process|
|regulation of cellular carbohydrate metabolic process|
|nucleic acid binding|
|regulation of carbohydrate metabolic process|
|protein dephosphorylation|
|dephosphorylation|
|regulation of small molecule metabolic process|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|zinc ion binding|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of catalytic activity|
|regulation of phosphorylation|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.8|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.85|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.434|
|[[:human genes:u:utp23|UTP23]]|0.429|
|[[:human genes:a:alg1|ALG1]]|0.428|
|[[:human genes:t:tamm41|TAMM41]]|0.426|
|[[:human genes:s:srp14|SRP14]]|0.424|
|[[:human genes:t:triap1|TRIAP1]]|0.422|
|[[:human genes:t:taz|TAZ]]|0.418|
|[[:human genes:u:urm1|URM1]]|0.418|
|[[:human genes:k:kdsr|KDSR]]|0.417|
|[[:human genes:g:gmppb|GMPPB]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.409|
|[[:human genes:e:exoc4|EXOC4]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP12 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>