DUSP12

Entrez Summary: N/A
UniProt Summary: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4- methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of glucokinase activity
positive regulation of hexokinase activity
regulation of glucokinase activity
regulation of hexokinase activity
protein tyrosine/serine/threonine phosphatase activity
phosphatase activity
positive regulation of cellular carbohydrate metabolic process
positive regulation of carbohydrate metabolic process
kinase binding
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of glucose metabolic process
regulation of cellular carbohydrate metabolic process
nucleic acid binding
regulation of carbohydrate metabolic process
protein dephosphorylation
dephosphorylation
regulation of small molecule metabolic process
positive regulation of kinase activity
positive regulation of transferase activity
zinc ion binding
regulation of kinase activity
regulation of transferase activity
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of catalytic activity
regulation of phosphorylation
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process