DUSP15

Gene Information

Official Symbol: DUSP15
Official Name: dual specificity phosphatase 15
Aliases and Previous Symbols: N/A
Entrez ID: 128853
UniProt: Q9H1R2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). {ECO:0000269|PubMed:22792334}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14567
Expression level (log2 read counts): 1.0

Expression Distribution

protein tyrosine/serine/threonine phosphatase activity
phosphatase activity
protein tyrosine phosphatase activity
transforming growth factor beta receptor signaling pathway
peptidyl-tyrosine dephosphorylation
positive regulation of JNK cascade
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
transmembrane receptor protein serine/threonine kinase signaling pathway
protein dephosphorylation
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
dephosphorylation
cellular response to growth factor stimulus
response to growth factor
positive regulation of MAPK cascade
enzyme linked receptor protein signaling pathway
regulation of cellular response to stress
regulation of MAPK cascade
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation
response to endogenous stimulus
regulation of response to stress
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication