DUSP19

Gene Information

Official Symbol: DUSP19
Official Name: dual specificity phosphatase 19
Aliases and Previous Symbols: N/A
Entrez ID: 142679
UniProt: Q8WTR2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. {ECO:0000269|PubMed:12479873}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18743
Expression level (log2 read counts): 2.97

Expression Distribution

JUN kinase phosphatase activity
MAP-kinase scaffold activity
negative regulation of JUN kinase activity
mitogen-activated protein kinase kinase kinase binding
protein kinase activator activity
protein kinase inhibitor activity
negative regulation of JNK cascade
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
positive regulation of JUN kinase activity
negative regulation of MAP kinase activity
regulation of JUN kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
negative regulation of MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
protein dephosphorylation
negative regulation of protein kinase activity
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
dephosphorylation
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity