DUSP1 [The Human Chemical-Genetic Interaction Map Project]

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======= DUSP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP1
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1843|1843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28562|P28562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600714|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
|Rhodanese|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tyrosine/threonine phosphatase activity|
|negative regulation of p38MAPK cascade|
|negative regulation of monocyte chemotaxis|
|negative regulation of mononuclear cell migration|
|MAP kinase tyrosine/serine/threonine phosphatase activity|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|negative regulation of meiotic cell cycle|
|negative regulation of leukocyte chemotaxis|
|mitotic cell cycle arrest|
|mitogen-activated protein kinase binding|
|regulation of monocyte chemotaxis|
|inactivation of MAPK activity|
|regulation of cell cycle checkpoint|
|growth factor binding|
|response to testosterone|
|negative regulation of DNA biosynthetic process|
|regulation of p38MAPK cascade|
|protein tyrosine/serine/threonine phosphatase activity|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of leukocyte migration|
|negative regulation of stress-activated protein kinase signaling cascade|
|regulation of mononuclear cell migration|
|regulation of meiotic cell cycle|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of reproductive process|
|regulation of mitotic sister chromatid separation|
|negative regulation of chemotaxis|
|regulation of chromosome separation|
|protein serine/threonine phosphatase activity|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of mitotic sister chromatid segregation|
|negative regulation of MAP kinase activity|
|regulation of sister chromatid segregation|
|cellular response to chemokine|
|response to chemokine|
|response to cAMP|
|protein tyrosine phosphatase activity|
|regulation of chromosome segregation|
|peptidyl-tyrosine dephosphorylation|
|response to retinoic acid|
|regulation of DNA biosynthetic process|
|regulation of leukocyte chemotaxis|
|response to hydrogen peroxide|
|negative regulation of DNA metabolic process|
|negative regulation of protein serine/threonine kinase activity|
|response to organophosphorus|
|response to estradiol|
|response to glucocorticoid|
|cell cycle arrest|
|response to calcium ion|
|response to purine-containing compound|
|regulation of reproductive process|
|response to corticosteroid|
|negative regulation of MAPK cascade|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|response to ketone|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|protein dephosphorylation|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|response to antibiotic|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|dephosphorylation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|response to steroid hormone|
|regulation of MAP kinase activity|
|response to acid chemical|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of response to external stimulus|
|response to metal ion|
|response to oxidative stress|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.27|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.7|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.75|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>