DUSP1
Gene Information
- Official Symbol: DUSP1
- Official Name: dual specificity phosphatase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1843
- UniProt: P28562
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| DSPc |
| Rhodanese |
GO Terms
| protein tyrosine/threonine phosphatase activity |
| negative regulation of p38MAPK cascade |
| negative regulation of monocyte chemotaxis |
| negative regulation of mononuclear cell migration |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| regulation of mitotic cell cycle spindle assembly checkpoint |
| regulation of spindle checkpoint |
| regulation of mitotic spindle checkpoint |
| peptidyl-serine dephosphorylation |
| peptidyl-threonine dephosphorylation |
| negative regulation of meiotic cell cycle |
| negative regulation of leukocyte chemotaxis |
| mitotic cell cycle arrest |
| mitogen-activated protein kinase binding |
| regulation of monocyte chemotaxis |
| inactivation of MAPK activity |
| regulation of cell cycle checkpoint |
| growth factor binding |
| response to testosterone |
| negative regulation of DNA biosynthetic process |
| regulation of p38MAPK cascade |
| protein tyrosine/serine/threonine phosphatase activity |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of leukocyte migration |
| negative regulation of stress-activated protein kinase signaling cascade |
| regulation of mononuclear cell migration |
| regulation of meiotic cell cycle |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| negative regulation of reproductive process |
| regulation of mitotic sister chromatid separation |
| negative regulation of chemotaxis |
| regulation of chromosome separation |
| protein serine/threonine phosphatase activity |
| negative regulation of ERK1 and ERK2 cascade |
| regulation of mitotic sister chromatid segregation |
| negative regulation of MAP kinase activity |
| regulation of sister chromatid segregation |
| cellular response to chemokine |
| response to chemokine |
| response to cAMP |
| protein tyrosine phosphatase activity |
| regulation of chromosome segregation |
| peptidyl-tyrosine dephosphorylation |
| response to retinoic acid |
| regulation of DNA biosynthetic process |
| regulation of leukocyte chemotaxis |
| response to hydrogen peroxide |
| negative regulation of DNA metabolic process |
| negative regulation of protein serine/threonine kinase activity |
| response to organophosphorus |
| response to estradiol |
| response to glucocorticoid |
| cell cycle arrest |
| response to calcium ion |
| response to purine-containing compound |
| regulation of reproductive process |
| response to corticosteroid |
| negative regulation of MAPK cascade |
| regulation of mitotic nuclear division |
| regulation of nuclear division |
| response to ketone |
| response to reactive oxygen species |
| regulation of leukocyte migration |
| regulation of chemotaxis |
| protein dephosphorylation |
| negative regulation of protein kinase activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| negative regulation of cell migration |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| regulation of ERK1 and ERK2 cascade |
| response to antibiotic |
| response to light stimulus |
| negative regulation of mitotic cell cycle |
| dephosphorylation |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| response to steroid hormone |
| regulation of MAP kinase activity |
| response to acid chemical |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| negative regulation of response to external stimulus |
| response to metal ion |
| response to oxidative stress |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| response to radiation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| negative regulation of intracellular signal transduction |
| response to toxic substance |
| regulation of protein serine/threonine kinase activity |
| response to inorganic substance |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| positive regulation of cell death |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| regulation of transferase activity |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| cell cycle process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| negative regulation of cellular protein metabolic process |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| regulation of organelle organization |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13529
- Expression level (log2 read counts): 5.96
Expression Distribution
DUSP1 Expression in NALM6 Cells: 5.96
