DUSP21

Gene Information

Official Symbol: DUSP21
Official Name: dual specificity phosphatase 21
Aliases and Previous Symbols: N/A
Entrez ID: 63904
UniProt: Q9H596
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009].
UniProt Summary: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13106
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
Calcipotriol 5μM R08 exp464	1.87
Docetaxel 0.002μM R01 exp45	1.91
YM155 0.0002μM R01 exp61	2.07

MAP kinase tyrosine/serine/threonine phosphatase activity
extrinsic component of mitochondrial inner membrane
inactivation of MAPK activity
negative regulation of MAP kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
dephosphorylation
regulation of MAP kinase activity
mitochondrial matrix
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction
regulation of protein modification process