DUSP26

Gene Information

Official Symbol: DUSP26
Official Name: dual specificity phosphatase 26
Aliases and Previous Symbols: N/A
Entrez ID: 78986
UniProt: Q9BV47
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13869
Expression level (log2 read counts): -6.6

Expression Distribution

positive regulation of peptidyl-serine dephosphorylation
phosphoserine phosphatase activity
regulation of peptidyl-serine dephosphorylation
negative regulation of protein kinase activity by regulation of protein phosphorylation
phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
positive regulation of protein dephosphorylation
RNA polymerase II activating transcription factor binding
positive regulation of dephosphorylation
p53 binding
negative regulation of ERK1 and ERK2 cascade
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of protein dephosphorylation
negative regulation of MAPK cascade
regulation of dephosphorylation
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of ERK1 and ERK2 cascade
dephosphorylation
positive regulation of cell adhesion
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of cell adhesion
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
negative regulation of transcription by RNA polymerase II
regulation of kinase activity
regulation of transferase activity
Golgi apparatus
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
positive regulation of phosphorus metabolic process