DUSP3 [The Human Chemical-Genetic Interaction Map Project]

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======= DUSP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP3
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1845|1845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51452|P51452]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600183|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of focal adhesion disassembly|
|regulation of focal adhesion disassembly|
|MAP kinase phosphatase activity|
|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|
|negative regulation of T cell receptor signaling pathway|
|protein tyrosine kinase binding|
|negative regulation of antigen receptor-mediated signaling pathway|
|inactivation of MAPK activity|
|positive regulation of adherens junction organization|
|negative regulation of JNK cascade|
|immunological synapse|
|regulation of T cell receptor signaling pathway|
|protein tyrosine/serine/threonine phosphatase activity|
|cellular response to epidermal growth factor stimulus|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of epidermal growth factor receptor signaling pathway|
|phosphatase activity|
|response to epidermal growth factor|
|negative regulation of ERBB signaling pathway|
|receptor tyrosine kinase binding|
|negative regulation of chemotaxis|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of adherens junction organization|
|negative regulation of MAP kinase activity|
|cytoskeletal protein binding|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of cell junction assembly|
|regulation of ERBB signaling pathway|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of T cell activation|
|regulation of cell-matrix adhesion|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of lymphocyte activation|
|positive regulation of mitotic cell cycle|
|negative regulation of MAPK cascade|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of JNK cascade|
|negative regulation of cell activation|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|protein dephosphorylation|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|dephosphorylation|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|negative regulation of locomotion|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|positive regulation of cell cycle|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|protein kinase binding|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP3 Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>