DUSP3
Gene Information
- Official Symbol: DUSP3
- Official Name: dual specificity phosphatase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 1845
- UniProt: P51452
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.
Pfam Domains GO Terms
Pfam Domains
| DSPc |
GO Terms
| positive regulation of focal adhesion disassembly |
| regulation of focal adhesion disassembly |
| MAP kinase phosphatase activity |
| peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
| negative regulation of T cell receptor signaling pathway |
| protein tyrosine kinase binding |
| negative regulation of antigen receptor-mediated signaling pathway |
| inactivation of MAPK activity |
| positive regulation of adherens junction organization |
| negative regulation of JNK cascade |
| immunological synapse |
| regulation of T cell receptor signaling pathway |
| protein tyrosine/serine/threonine phosphatase activity |
| cellular response to epidermal growth factor stimulus |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of epidermal growth factor receptor signaling pathway |
| phosphatase activity |
| response to epidermal growth factor |
| negative regulation of ERBB signaling pathway |
| receptor tyrosine kinase binding |
| negative regulation of chemotaxis |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of ERK1 and ERK2 cascade |
| regulation of adherens junction organization |
| negative regulation of MAP kinase activity |
| cytoskeletal protein binding |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of cell junction assembly |
| regulation of ERBB signaling pathway |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| negative regulation of T cell activation |
| regulation of cell-matrix adhesion |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of lymphocyte activation |
| positive regulation of mitotic cell cycle |
| negative regulation of MAPK cascade |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| regulation of JNK cascade |
| negative regulation of cell activation |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| protein dephosphorylation |
| negative regulation of protein kinase activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| negative regulation of cell migration |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| dephosphorylation |
| negative regulation of cellular component movement |
| regulation of T cell activation |
| negative regulation of locomotion |
| regulation of MAP kinase activity |
| negative regulation of response to external stimulus |
| positive regulation of cell cycle |
| regulation of cell-cell adhesion |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| protein kinase binding |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| response to growth factor |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| regulation of cell adhesion |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7813
- Expression level (log2 read counts): 5.02
Expression Distribution
DUSP3 Expression in NALM6 Cells: 5.02
