DUSP5

Gene Information

Official Symbol: DUSP5
Official Name: dual specificity phosphatase 5
Aliases and Previous Symbols: N/A
Entrez ID: 1847
UniProt: Q16690
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. {ECO:0000269|PubMed:7961985}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17036
Expression level (log2 read counts): 0.5

Expression Distribution

Screen	Score
DABN racemic mixture R03 exp93	-2.32
GSK-J5 1.5μM R08 exp484	1.88
Cabazitaxel 0.001μM R05 exp223	2.13

Y phosphatase
Rhodanese
DSPc

MAP kinase tyrosine/serine/threonine phosphatase activity
peptidyl-threonine dephosphorylation
inactivation of MAPK activity
protein tyrosine/serine/threonine phosphatase activity
phosphatase activity
negative regulation of MAP kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
activation of MAPK activity
negative regulation of MAPK cascade
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
dephosphorylation
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity
negative regulation of protein modification process
positive regulation of transferase activity
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation