DUSP6 [The Human Chemical-Genetic Interaction Map Project]

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======= DUSP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP6
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1848|1848]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16828|Q16828]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:8670865}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
|Rhodanese|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to nitrosative stress|
|MAP kinase tyrosine/serine/threonine phosphatase activity|
|inactivation of MAPK activity|
|protein tyrosine/serine/threonine phosphatase activity|
|regulation of heart growth|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of MAP kinase activity|
|regulation of organ growth|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of protein serine/threonine kinase activity|
|activation of MAPK activity|
|negative regulation of MAPK cascade|
|protein dephosphorylation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|positive regulation of MAP kinase activity|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|dephosphorylation|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of growth|
|positive regulation of cell death|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.73|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.7|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.74|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.81|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.81|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.9|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.14|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.15|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.22|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.27|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.28|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.4|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.51|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.54|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.6|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.81|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nf1|NF1]]|0.486|
|[[:human genes:r:rfwd2|RFWD2]]|0.475|
|[[:human genes:l:lztr1|LZTR1]]|0.454|
|[[:human genes:s:spred2|SPRED2]]|0.453|
|[[:human genes:d:dgkd|DGKD]]|0.427|
|[[:human genes:r:rasa2|RASA2]]|0.421|
|[[:human genes:z:zdhhc17|ZDHHC17]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP6 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>