DUSP6

Gene Information

Official Symbol: DUSP6
Official Name: dual specificity phosphatase 6
Aliases and Previous Symbols: N/A
Entrez ID: 1848
UniProt: Q16828
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014].
UniProt Summary: Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:8670865}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.73
Dorsomorphin 5μM R07 exp357	1.7
Sulforaphane 9μM R08 exp525	1.74
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.81
Tubacin 1.6μM R07 exp416	1.81
Wortmannin 0.5μM R00 exp37	1.9
Ibrutinib 10μM R08 exp442	2.14
GW501516 25μM R06 exp285	2.15
VER-155008 3.9μM R06 exp301	2.22
TRAIL 5ng/ml R00 exp35	2.27
GSK626616 14μM R08 exp485	2.28
CAY10603 0.55μM R08 exp467	2.4
Olaparib 4μM R08 exp512	2.51
I-BRD9 4μM R07 exp365	2.54
AICAR 240μM R03 exp116	2.6
Wortmannin 5μM R00 exp38	2.81
Nutlin-3A 1.6μM R06 exp294	2.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16333
Expression level (log2 read counts): 4.93

Expression Distribution

Gene	Correlation
NF1	0.486
RFWD2	0.475
LZTR1	0.454
SPRED2	0.453
DGKD	0.427
RASA2	0.421
ZDHHC17	0.419

DSPc
Rhodanese

response to nitrosative stress
MAP kinase tyrosine/serine/threonine phosphatase activity
inactivation of MAPK activity
protein tyrosine/serine/threonine phosphatase activity
regulation of heart growth
negative regulation of ERK1 and ERK2 cascade
negative regulation of MAP kinase activity
regulation of organ growth
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
activation of MAPK activity
negative regulation of MAPK cascade
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
regulation of ERK1 and ERK2 cascade
dephosphorylation
activation of protein kinase activity
regulation of developmental growth
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
response to growth factor
positive regulation of protein kinase activity
positive regulation of MAPK cascade
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity
negative regulation of protein modification process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity