DUSP7

Gene Information

Official Symbol: DUSP7
Official Name: dual specificity phosphatase 7
Aliases and Previous Symbols: N/A
Entrez ID: 1849
UniProt: Q16829
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. {ECO:0000269|PubMed:14603440}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ibrutinib 1μM R07 exp372	1.71
BRD2 inhibitor II 20μM R07 exp341	1.73
Pifithrin-alpha 20μM R07 exp390	1.75
Diepoxybutane 3μM R07 exp354	1.76
PF-06409577 20μM R07 exp389	1.84
Dexamethasone 0.006μM R07 exp351	1.97
BN82002 4μM R07 exp340	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15120
Expression level (log2 read counts): 5.05

Expression Distribution

DSPc
Rhodanese

MAP kinase tyrosine/serine/threonine phosphatase activity
inactivation of MAPK activity
protein tyrosine/serine/threonine phosphatase activity
negative regulation of MAP kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
activation of MAPK activity
negative regulation of MAPK cascade
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
dephosphorylation
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity
negative regulation of protein modification process
positive regulation of transferase activity
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process