DUT

Gene Information

Official Symbol: DUT
Official Name: deoxyuridine triphosphatase
Aliases and Previous Symbols: N/A
Entrez ID: 1854
UniProt: P33316
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 729/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	28/28
blood	28/28
bone	24/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 4607
Expression level (log2 read counts): 7.61

Expression Distribution

dUTP catabolic process
dUTP diphosphatase activity
dUTP metabolic process
pyrimidine nucleoside triphosphate catabolic process
pyrimidine deoxyribonucleoside triphosphate catabolic process
dUMP biosynthetic process
dUMP metabolic process
pyrimidine deoxyribonucleoside monophosphate biosynthetic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
deoxyribonucleoside triphosphate catabolic process
pyrimidine deoxyribonucleotide biosynthetic process
deoxyribonucleoside monophosphate biosynthetic process
2-deoxyribonucleotide biosynthetic process
deoxyribose phosphate biosynthetic process
deoxyribonucleoside monophosphate metabolic process
nucleoside triphosphate catabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleotide catabolic process
deoxyribonucleotide biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide catabolic process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate catabolic process
pyrimidine nucleoside triphosphate metabolic process
nucleobase-containing small molecule interconversion
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
pyrimidine-containing compound catabolic process
nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside monophosphate metabolic process
nucleoside triphosphate metabolic process