DVL1
Gene Information
- Official Symbol: DVL1
- Official Name: dishevelled segment polarity protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1855
- UniProt: O14640
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008].
- UniProt Summary: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Pfam Domains GO Terms
Pfam Domains
| Dsh C |
| Dishevelled |
| PDZ |
| DIX |
| DEP |
GO Terms
| regulation of protein localization to presynapse |
| positive regulation of protein localization to presynapse |
| convergent extension involved in neural plate elongation |
| neural plate elongation |
| convergent extension involved in organogenesis |
| neural plate morphogenesis |
| skeletal muscle acetylcholine-gated channel clustering |
| convergent extension involved in gastrulation |
| positive regulation of neuron projection arborization |
| collateral sprouting |
| positive regulation of protein localization to synapse |
| regulation of neuron projection arborization |
| neural plate development |
| protein localization to microtubule |
| Wnt signalosome |
| planar cell polarity pathway involved in neural tube closure |
| convergent extension |
| regulation of establishment of planar polarity involved in neural tube closure |
| prepulse inhibition |
| dendritic spine morphogenesis |
| regulation of epithelial tube formation |
| presynapse assembly |
| beta-catenin destruction complex disassembly |
| presynapse organization |
| cochlea morphogenesis |
| regulation of protein localization to synapse |
| startle response |
| positive regulation of excitatory postsynaptic potential |
| dendritic spine development |
| postsynaptic membrane organization |
| dendritic spine organization |
| protein localization to microtubule cytoskeleton |
| axon extension |
| protein localization to cytoskeleton |
| frizzled binding |
| modulation of excitatory postsynaptic potential |
| neuron projection organization |
| neuromuscular junction development |
| receptor clustering |
| morphogenesis of an epithelial sheet |
| cochlea development |
| intraspecies interaction between organisms |
| social behavior |
| cytoplasmic microtubule organization |
| Rac GTPase binding |
| clathrin-coated vesicle |
| lateral plasma membrane |
| dendrite morphogenesis |
| neuron projection extension |
| positive regulation of nervous system process |
| multi-organism behavior |
| regulation of synaptic vesicle exocytosis |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Schaffer collateral - CA1 synapse |
| beta-catenin binding |
| localization within membrane |
| developmental cell growth |
| postsynapse organization |
| canonical Wnt signaling pathway |
| cell growth |
| neural tube closure |
| tube closure |
| synapse assembly |
| presynapse |
| Wnt signaling pathway, planar cell polarity pathway |
| primary neural tube formation |
| positive regulation of ubiquitin-dependent protein catabolic process |
| inner ear morphogenesis |
| signal release from synapse |
| neurotransmitter secretion |
| negative regulation of protein binding |
| dendrite development |
| positive regulation of proteasomal protein catabolic process |
| regulation of neurotransmitter secretion |
| neural tube formation |
| neuromuscular process |
| regulation of establishment of planar polarity |
| regulation of synaptic vesicle cycle |
| developmental growth involved in morphogenesis |
| ear morphogenesis |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| embryonic epithelial tube formation |
| regulation of embryonic development |
| growth cone |
| epithelial tube formation |
| non-canonical Wnt signaling pathway |
| regulation of nervous system process |
| positive regulation of cellular protein catabolic process |
| regulation of neurotransmitter transport |
| morphogenesis of embryonic epithelium |
| tube formation |
| dendritic spine |
| positive regulation of synaptic transmission |
| regulation of ubiquitin-dependent protein catabolic process |
| gastrulation |
| neural tube development |
| protein localization to nucleus |
| regulation of regulated secretory pathway |
| signal release |
| negative regulation of binding |
| negative regulation of canonical Wnt signaling pathway |
| protein stabilization |
| neurotransmitter transport |
| regulation of morphogenesis of an epithelium |
| regulation of proteasomal protein catabolic process |
| inner ear development |
| negative regulation of Wnt signaling pathway |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| regulation of protein binding |
| ear development |
| regulation of exocytosis |
| negative regulation of protein kinase activity |
| protein-containing complex disassembly |
| negative regulation of kinase activity |
| regulation of cellular protein catabolic process |
| cytoplasmic vesicle |
| postsynaptic density |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| axon guidance |
| neuron projection guidance |
| synapse |
| synapse organization |
| negative regulation of transferase activity |
| positive regulation of neuron projection development |
| regulation of canonical Wnt signaling pathway |
| regulation of protein stability |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| microtubule |
| neuron projection |
| glutamatergic synapse |
| enzyme binding |
| regulation of neurotransmitter levels |
| Wnt signaling pathway |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| positive regulation of neuron differentiation |
| neuronal cell body |
| axonogenesis |
| regulation of binding |
| positive regulation of cell projection organization |
| regulation of protein catabolic process |
| developmental growth |
| growth |
| cellular component disassembly |
| negative regulation of protein phosphorylation |
| axon development |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| positive regulation of catabolic process |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| supramolecular fiber organization |
| synaptic signaling |
| protein kinase binding |
| positive regulation of neurogenesis |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| protein localization to membrane |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of nervous system development |
| regulation of cellular protein localization |
| positive regulation of cell development |
| sensory organ development |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| behavior |
| regulation of system process |
| negative regulation of protein modification process |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| microtubule-based process |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of proteolysis |
| protein localization to organelle |
| regulation of secretion by cell |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| tube development |
| membrane organization |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| regulation of catabolic process |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| epithelium development |
| cell-cell signaling |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| regulation of protein phosphorylation |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| RNA metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8260
- Expression level (log2 read counts): 4.84
Expression Distribution
DVL1 Expression in NALM6 Cells: 4.84
