DVL2 [The Human Chemical-Genetic Interaction Map Project]

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======= DVL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DVL2
  * **<color #00a2e8>Official Name</color>**: dishevelled segment polarity protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1856|1856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14641|O14641]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DVL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DVL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602151|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dsh C|
|DEP|
|Dishevelled|
|PDZ|
|DIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neural plate elongation|
|convergent extension involved in neural plate elongation|
|canonical Wnt signaling pathway involved in regulation of cell proliferation|
|convergent extension involved in organogenesis|
|neural plate morphogenesis|
|positive regulation of neuron projection arborization|
|convergent extension involved in gastrulation|
|neural plate development|
|regulation of neuron projection arborization|
|planar cell polarity pathway involved in neural tube closure|
|convergent extension|
|regulation of establishment of planar polarity involved in neural tube closure|
|segment specification|
|regulation of epithelial tube formation|
|beta-catenin destruction complex disassembly|
|cochlea morphogenesis|
|clathrin-coated endocytic vesicle|
|hippo signaling|
|frizzled binding|
|aggresome|
|morphogenesis of an epithelial sheet|
|cochlea development|
|Rac GTPase binding|
|positive regulation of protein tyrosine kinase activity|
|protein self-association|
|lateral plasma membrane|
|apical part of cell|
|positive regulation of JUN kinase activity|
|outflow tract morphogenesis|
|protein binding, bridging|
|regulation of JUN kinase activity|
|regulation of protein tyrosine kinase activity|
|canonical Wnt signaling pathway|
|neural tube closure|
|tube closure|
|segmentation|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|neural tube formation|
|regulation of establishment of planar polarity|
|ear morphogenesis|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|positive regulation of JNK cascade|
|morphogenesis of embryonic epithelium|
|tube formation|
|gastrulation|
|neural tube development|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|negative regulation of canonical Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|regulation of JNK cascade|
|positive regulation of peptidyl-tyrosine phosphorylation|
|inner ear development|
|negative regulation of Wnt signaling pathway|
|ear development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|protein-containing complex disassembly|
|protein domain specific binding|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|cytoplasmic vesicle|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|nuclear body|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|cellular component disassembly|
|positive regulation of GTPase activity|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|protein kinase binding|
|positive regulation of neurogenesis|
|transcription by RNA polymerase II|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|tube development|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DVL2 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>