DVL2

Entrez Summary: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neural plate elongation
convergent extension involved in neural plate elongation
canonical Wnt signaling pathway involved in regulation of cell proliferation
convergent extension involved in organogenesis
neural plate morphogenesis
positive regulation of neuron projection arborization
convergent extension involved in gastrulation
neural plate development
regulation of neuron projection arborization
planar cell polarity pathway involved in neural tube closure
convergent extension
regulation of establishment of planar polarity involved in neural tube closure
segment specification
regulation of epithelial tube formation
beta-catenin destruction complex disassembly
cochlea morphogenesis
clathrin-coated endocytic vesicle
hippo signaling
frizzled binding
aggresome
morphogenesis of an epithelial sheet
cochlea development
Rac GTPase binding
positive regulation of protein tyrosine kinase activity
protein self-association
lateral plasma membrane
apical part of cell
positive regulation of JUN kinase activity
outflow tract morphogenesis
protein binding, bridging
regulation of JUN kinase activity
regulation of protein tyrosine kinase activity
canonical Wnt signaling pathway
neural tube closure
tube closure
segmentation
Wnt signaling pathway, planar cell polarity pathway
inner ear morphogenesis
primary neural tube formation
neural tube formation