E2F3

Gene Information

Official Symbol: E2F3
Official Name: E2F transcription factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 1871
UniProt: O00716
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
UniProt Summary: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 28/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	1/26
breast	0/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	1/1
gastric	0/16
kidney	0/21
liver	0/20
lung	6/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 4203
Expression level (log2 read counts): 6.48

Expression Distribution

negative regulation of fat cell proliferation
positive regulation of vascular associated smooth muscle cell apoptotic process
regulation of vascular associated smooth muscle cell apoptotic process
regulation of fat cell proliferation
positive regulation of smooth muscle cell apoptotic process
regulation of smooth muscle cell apoptotic process
positive regulation of muscle cell apoptotic process
proximal promoter sequence-specific DNA binding
regulation of muscle cell apoptotic process
RNA polymerase II transcription factor complex
protein dimerization activity
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor binding
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
positive regulation of apoptotic process
positive regulation of programmed cell death
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of cell population proliferation
positive regulation of cell death
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of cellular macromolecule biosynthetic process