E2F6

Gene Information

Official Symbol: E2F6
Official Name: E2F transcription factor 6
Aliases and Previous Symbols: N/A
Entrez ID: 1876
UniProt: O75461
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 29/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	7/75
lymphocyte	2/14
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4656
Expression level (log2 read counts): 5.03

Expression Distribution

regulation of transcription involved in G1/S transition of mitotic cell cycle
MLL1 complex
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
RNA polymerase II transcription factor complex
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
protein dimerization activity
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
mitotic cell cycle phase transition
cell cycle phase transition
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell cycle process
transcription factor binding
sequence-specific DNA binding
negative regulation of cell cycle
mitotic cell cycle process
DNA-binding transcription factor activity
mitotic cell cycle
regulation of cell cycle process
negative regulation of transcription by RNA polymerase II
cell cycle process
regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process