E2F8 [The Human Chemical-Genetic Interaction Map Project]

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======= E2F8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: E2F8
  * **<color #00a2e8>Official Name</color>**: E2F transcription factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79733|79733]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A0AVK6|A0AVK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=E2F8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20E2F8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612047|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E2F TDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell cycle comprising mitosis without cytokinesis|
|positive regulation of DNA endoreduplication|
|chorionic trophoblast cell differentiation|
|negative regulation of cytokinesis|
|chorion development|
|extraembryonic membrane development|
|regulation of DNA endoreduplication|
|positive regulation of DNA-dependent DNA replication|
|trophoblast giant cell differentiation|
|hepatocyte differentiation|
|negative regulation of cell division|
|cell differentiation involved in embryonic placenta development|
|proximal promoter sequence-specific DNA binding|
|positive regulation of DNA replication|
|regulation of DNA-dependent DNA replication|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|sprouting angiogenesis|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|RNA polymerase II transcription factor complex|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|embryonic placenta development|
|regulation of cytokinesis|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|regulation of DNA replication|
|signal transduction by p53 class mediator|
|liver development|
|hepaticobiliary system development|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|placenta development|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|angiogenesis|
|negative regulation of cell cycle process|
|transcription factor binding|
|positive regulation of cell cycle|
|in utero embryonic development|
|blood vessel morphogenesis|
|gland development|
|regulation of mitotic cell cycle phase transition|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|regulation of cell cycle phase transition|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|mitotic cell cycle|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|cell cycle process|
|epithelium development|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.92|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.88|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.77|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.75|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.72|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.73|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.82|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.9|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.29|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10849
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='E2F8 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>