EARS2 [The Human Chemical-Genetic Interaction Map Project]

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======= EARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EARS2
  * **<color #00a2e8>Official Name</color>**: glutamyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124454|124454]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JPH6|Q5JPH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612799|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1c|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate-tRNA(Gln) ligase activity|
|glutamate-tRNA ligase activity|
|glutamyl-tRNA aminoacylation|
|tRNA aminoacylation for mitochondrial protein translation|
|mitochondrial RNA metabolic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|zinc ion binding|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.02|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.01|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.89|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.84|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.83|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.81|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.7|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.78|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.8|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.87|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.98|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.21|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.29|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.32|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.13|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|3.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.746|
|[[:human genes:n:nars2|NARS2]]|0.728|
|[[:human genes:m:mrpl21|MRPL21]]|0.725|
|[[:human genes:y:yars2|YARS2]]|0.722|
|[[:human genes:q:qrsl1|QRSL1]]|0.719|
|[[:human genes:d:dap3|DAP3]]|0.712|
|[[:human genes:l:lars2|LARS2]]|0.711|
|[[:human genes:m:mrps21|MRPS21]]|0.695|
|[[:human genes:t:tars2|TARS2]]|0.695|
|[[:human genes:s:sco2|SCO2]]|0.691|
|[[:human genes:m:mrps6|MRPS6]]|0.686|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.681|
|[[:human genes:c:coa3|COA3]]|0.68|
|[[:human genes:m:mrps34|MRPS34]]|0.676|
|[[:human genes:p:pars2|PARS2]]|0.674|
|[[:human genes:f:fastkd5|FASTKD5]]|0.663|
|[[:human genes:p:pet112|PET112]]|0.659|
|[[:human genes:m:mrpl53|MRPL53]]|0.644|
|[[:human genes:m:mrps16|MRPS16]]|0.643|
|[[:human genes:g:gfm1|GFM1]]|0.643|
|[[:human genes:a:aars2|AARS2]]|0.642|
|[[:human genes:v:vars2|VARS2]]|0.639|
|[[:human genes:m:mrps5|MRPS5]]|0.631|
|[[:human genes:c:coa6|COA6]]|0.63|
|[[:human genes:c:cox16|COX16]]|0.627|
|[[:human genes:h:hars2|HARS2]]|0.625|
|[[:human genes:r:rpusd4|RPUSD4]]|0.622|
|[[:human genes:p:pet117|PET117]]|0.621|
|[[:human genes:m:mrpl23|MRPL23]]|0.62|
|[[:human genes:m:mtg2|MTG2]]|0.618|
|[[:human genes:r:rars2|RARS2]]|0.618|
|[[:human genes:g:gatc|GATC]]|0.616|
|[[:human genes:d:dars2|DARS2]]|0.615|
|[[:human genes:b:bcs1l|BCS1L]]|0.612|
|[[:human genes:t:tefm|TEFM]]|0.612|
|[[:human genes:m:mars2|MARS2]]|0.61|
|[[:human genes:r:rbfa|RBFA]]|0.601|
|[[:human genes:m:mrps24|MRPS24]]|0.6|
|[[:human genes:f:ftsj2|FTSJ2]]|0.599|
|[[:human genes:m:mrps14|MRPS14]]|0.597|
|[[:human genes:n:ndufb11|NDUFB11]]|0.597|
|[[:human genes:c:cox11|COX11]]|0.595|
|[[:human genes:m:mrpl47|MRPL47]]|0.594|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.589|
|[[:human genes:m:mrps26|MRPS26]]|0.588|
|[[:human genes:m:mrp63|MRP63]]|0.584|
|[[:human genes:m:mrps10|MRPS10]]|0.581|
|[[:human genes:c:c10orf2|C10orf2]]|0.579|
|[[:human genes:s:sars2|SARS2]]|0.578|
|[[:human genes:g:gfm2|GFM2]]|0.576|
|[[:human genes:w:wbscr16|WBSCR16]]|0.576|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.575|
|[[:human genes:w:wars2|WARS2]]|0.572|
|[[:human genes:m:mrps2|MRPS2]]|0.571|
|[[:human genes:m:mrps18a|MRPS18A]]|0.57|
|[[:human genes:t:tmem242|TMEM242]]|0.564|
|[[:human genes:m:mrps25|MRPS25]]|0.563|
|[[:human genes:p:polg2|POLG2]]|0.563|
|[[:human genes:m:mrpl20|MRPL20]]|0.562|
|[[:human genes:m:mettl17|METTL17]]|0.561|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.56|
|[[:human genes:c:c12orf65|C12orf65]]|0.56|
|[[:human genes:c:cox7b|COX7B]]|0.559|
|[[:human genes:m:mrps35|MRPS35]]|0.557|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.554|
|[[:human genes:m:mrpl45|MRPL45]]|0.554|
|[[:human genes:c:cox20|COX20]]|0.554|
|[[:human genes:c:cox15|COX15]]|0.549|
|[[:human genes:m:mrpl12|MRPL12]]|0.548|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.547|
|[[:human genes:f:fars2|FARS2]]|0.546|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.544|
|[[:human genes:m:mrpl42|MRPL42]]|0.541|
|[[:human genes:t:tomm20|TOMM20]]|0.54|
|[[:human genes:n:ndufa3|NDUFA3]]|0.539|
|[[:human genes:p:polg|POLG]]|0.539|
|[[:human genes:m:mtg1|MTG1]]|0.539|
|[[:human genes:c:cars2|CARS2]]|0.53|
|[[:human genes:p:polrmt|POLRMT]]|0.527|
|[[:human genes:m:mrps23|MRPS23]]|0.526|
|[[:human genes:m:mrps12|MRPS12]]|0.524|
|[[:human genes:n:ndufa2|NDUFA2]]|0.523|
|[[:human genes:m:mrps27|MRPS27]]|0.522|
|[[:human genes:m:mrps33|MRPS33]]|0.518|
|[[:human genes:r:rpusd3|RPUSD3]]|0.518|
|[[:human genes:a:aifm1|AIFM1]]|0.516|
|[[:human genes:s:slc25a26|SLC25A26]]|0.515|
|[[:human genes:a:atp5sl|ATP5SL]]|0.514|
|[[:human genes:t:trmt61a|TRMT61A]]|0.514|
|[[:human genes:t:tufm|TUFM]]|0.513|
|[[:human genes:m:mtif2|MTIF2]]|0.512|
|[[:human genes:p:pgm3|PGM3]]|0.509|
|[[:human genes:m:mrpl18|MRPL18]]|0.507|
|[[:human genes:m:mrps9|MRPS9]]|0.505|
|[[:human genes:m:mrpl43|MRPL43]]|0.504|
|[[:human genes:c:c17orf89|C17orf89]]|0.504|
|[[:human genes:m:mtif3|MTIF3]]|0.504|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.503|
|[[:human genes:m:mcat|MCAT]]|0.503|
|[[:human genes:c:coq2|COQ2]]|0.502|
|[[:human genes:c:coq7|COQ7]]|0.5|
|[[:human genes:m:mrpl15|MRPL15]]|0.5|
|[[:human genes:m:mipep|MIPEP]]|0.499|
|[[:human genes:n:ndufb5|NDUFB5]]|0.499|
|[[:human genes:d:dhrsx|DHRSX]]|0.498|
|[[:human genes:m:mrpl44|MRPL44]]|0.496|
|[[:human genes:a:atp5c1|ATP5C1]]|0.496|
|[[:human genes:c:coq4|COQ4]]|0.494|
|[[:human genes:c:clpp|CLPP]]|0.49|
|[[:human genes:l:lrpprc|LRPPRC]]|0.489|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.489|
|[[:human genes:p:pnpt1|PNPT1]]|0.488|
|[[:human genes:d:dnlz|DNLZ]]|0.488|
|[[:human genes:m:mtpap|MTPAP]]|0.488|
|[[:human genes:m:mrps22|MRPS22]]|0.487|
|[[:human genes:m:mrpl55|MRPL55]]|0.487|
|[[:human genes:p:pdss1|PDSS1]]|0.487|
|[[:human genes:c:cox17|COX17]]|0.487|
|[[:human genes:m:mrpl39|MRPL39]]|0.486|
|[[:human genes:p:pitrm1|PITRM1]]|0.486|
|[[:human genes:f:fastkd1|FASTKD1]]|0.484|
|[[:human genes:e:ecsit|ECSIT]]|0.484|
|[[:human genes:a:atp5d|ATP5D]]|0.484|
|[[:human genes:t:trub2|TRUB2]]|0.482|
|[[:human genes:n:ndufs2|NDUFS2]]|0.481|
|[[:human genes:d:ddx28|DDX28]]|0.481|
|[[:human genes:m:mrpl11|MRPL11]]|0.48|
|[[:human genes:m:mrps28|MRPS28]]|0.478|
|[[:human genes:m:mrpl3|MRPL3]]|0.475|
|[[:human genes:p:pmvk|PMVK]]|0.473|
|[[:human genes:u:uqcr10|UQCR10]]|0.47|
|[[:human genes:p:pet100|PET100]]|0.469|
|[[:human genes:m:mrpl22|MRPL22]]|0.468|
|[[:human genes:e:eral1|ERAL1]]|0.468|
|[[:human genes:f:fh|FH]]|0.466|
|[[:human genes:a:acad9|ACAD9]]|0.465|
|[[:human genes:m:mrpl35|MRPL35]]|0.463|
|[[:human genes:m:mterfd1|MTERFD1]]|0.462|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.462|
|[[:human genes:m:mrps7|MRPS7]]|0.461|
|[[:human genes:c:chchd4|CHCHD4]]|0.461|
|[[:human genes:m:mrpl4|MRPL4]]|0.461|
|[[:human genes:m:mrps11|MRPS11]]|0.46|
|[[:human genes:m:mterfd2|MTERFD2]]|0.46|
|[[:human genes:n:ndufa1|NDUFA1]]|0.459|
|[[:human genes:n:ndufc2|NDUFC2]]|0.457|
|[[:human genes:i:iba57|IBA57]]|0.454|
|[[:human genes:a:atp5a1|ATP5A1]]|0.454|
|[[:human genes:l:lsm10|LSM10]]|0.453|
|[[:human genes:c:cox5a|COX5A]]|0.452|
|[[:human genes:m:malsu1|MALSU1]]|0.451|
|[[:human genes:r:rpia|RPIA]]|0.451|
|[[:human genes:n:ndufa10|NDUFA10]]|0.448|
|[[:human genes:m:mrpl17|MRPL17]]|0.448|
|[[:human genes:n:ndufb6|NDUFB6]]|0.447|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.447|
|[[:human genes:m:mrpl33|MRPL33]]|0.446|
|[[:human genes:m:mrpl51|MRPL51]]|0.446|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.445|
|[[:human genes:c:coq3|COQ3]]|0.443|
|[[:human genes:m:minos1|MINOS1]]|0.443|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.442|
|[[:human genes:h:higd2a|HIGD2A]]|0.442|
|[[:human genes:m:mrpl1|MRPL1]]|0.441|
|[[:human genes:o:opa1|OPA1]]|0.44|
|[[:human genes:n:ndufs7|NDUFS7]]|0.44|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.439|
|[[:human genes:f:fastkd2|FASTKD2]]|0.439|
|[[:human genes:m:mrpl36|MRPL36]]|0.439|
|[[:human genes:t:triap1|TRIAP1]]|0.438|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.435|
|[[:human genes:t:tfb1m|TFB1M]]|0.434|
|[[:human genes:n:ndufa11|NDUFA11]]|0.431|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.43|
|[[:human genes:t:timm8b|TIMM8B]]|0.43|
|[[:human genes:m:mrpl34|MRPL34]]|0.429|
|[[:human genes:m:mrps17|MRPS17]]|0.428|
|[[:human genes:m:mrpl49|MRPL49]]|0.428|
|[[:human genes:n:ndufb9|NDUFB9]]|0.426|
|[[:human genes:t:tomm6|TOMM6]]|0.425|
|[[:human genes:g:grsf1|GRSF1]]|0.425|
|[[:human genes:p:ppcdc|PPCDC]]|0.423|
|[[:human genes:c:c1qbp|C1QBP]]|0.422|
|[[:human genes:i:ict1|ICT1]]|0.421|
|[[:human genes:n:ndufa8|NDUFA8]]|0.421|
|[[:human genes:m:mrpl41|MRPL41]]|0.419|
|[[:human genes:p:ptcd1|PTCD1]]|0.418|
|[[:human genes:n:ndufv1|NDUFV1]]|0.418|
|[[:human genes:c:cox19|COX19]]|0.418|
|[[:human genes:t:tfam|TFAM]]|0.417|
|[[:human genes:t:tomm40|TOMM40]]|0.416|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.415|
|[[:human genes:a:atp5b|ATP5B]]|0.415|
|[[:human genes:c:cox6b1|COX6B1]]|0.415|
|[[:human genes:c:cox6c|COX6C]]|0.414|
|[[:human genes:m:mrpl2|MRPL2]]|0.41|
|[[:human genes:s:ssbp1|SSBP1]]|0.41|
|[[:human genes:p:ppa2|PPA2]]|0.41|
|[[:human genes:p:ptcd3|PTCD3]]|0.409|
|[[:human genes:s:slc25a3|SLC25A3]]|0.407|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.407|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.405|
|[[:human genes:p:pdss2|PDSS2]]|0.405|
|[[:human genes:m:mto1|MTO1]]|0.405|
|[[:human genes:a:atp5h|ATP5H]]|0.404|
|[[:human genes:t:tfb2m|TFB2M]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|6/28|
|bone|7/26|
|breast|11/33|
|central nervous system|8/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|5/21|
|liver|7/20|
|lung|21/75|
|lymphocyte|4/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|10/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EARS2 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>