EARS2
Gene Information
- Official Symbol: EARS2
- Official Name: glutamyl-tRNA synthetase 2, mitochondrial
- Aliases and Previous Symbols: N/A
- Entrez ID: 124454
- UniProt: Q5JPH6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
- UniProt Summary: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 679
- Expression level (log2 read counts): 5.43
EARS2 Expression in NALM6 Cells: 5.43
