EBF1 [The Human Chemical-Genetic Interaction Map Project]

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======= EBF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EBF1
  * **<color #00a2e8>Official Name</color>**: EBF transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1879|1879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UH73|Q9UH73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EBF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EBF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164343|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C2H2 zinc finger domain binding|
|protein dimerization activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.72|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.73|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.77|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.77|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.78|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.85|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.92|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.2|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.21|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.4|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.53|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.6|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.67|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.7|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.1|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.62|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|4/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EBF1 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>