EBF1

Entrez Summary: N/A
UniProt Summary: Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pyridostatin 4μM R05 exp240	1.72
Vinblastine 0.015μM R05 exp208	1.73
Fluvastatin 2.2μM R06 exp282	1.77
Wortmannin 0.5μM R00 exp37	1.77
2-Deoxy-D-glucose 800μM R05 exp214	1.78
FK-506 30μM R07 exp359	1.81
THZ531 0.225μM R08 exp444	1.85
UM0129480 7μM R02 exp85	1.9
Sulforaphane 9μM R08 exp525	1.92
Rucaparib 6.5μM R08 exp520	2.1
Doxorubicin 0.02μM R08 exp478	2.2
Etoposide 0.3μM R05 exp199	2.21
Calcium Ionophore 0.4μM R07 exp342	2.4
Dinaciclib 0.007μM R07 exp355	2.53
Lead acetate 2000μM R08 exp498 no dilution day6	2.6
CB-5083 0.4μM R08 exp468	2.67
Dorsomorphin 5μM R07 exp357	2.7
Actinomycin-D 0.001μM R00 exp3	3.1
Bortezomib 0.005μM R00 exp6	3.62
Thapsigargin 0.005μM R07 exp407	3.82

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	3/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	4/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2H2 zinc finger domain binding
protein dimerization activity
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process