EDA2R [The Human Chemical-Genetic Interaction Map Project]

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======= EDA2R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDA2R
  * **<color #00a2e8>Official Name</color>**: ectodysplasin A2 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60401|60401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAV5|Q9HAV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDA2R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDA2R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300276|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ectodermal cell differentiation|
|tumor necrosis factor-activated receptor activity|
|ectoderm development|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|tumor necrosis factor-mediated signaling pathway|
|signal transduction by p53 class mediator|
|positive regulation of JNK cascade|
|intrinsic apoptotic signaling pathway|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|signaling receptor activity|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|apoptotic signaling pathway|
|epidermis development|
|regulation of DNA-binding transcription factor activity|
|positive regulation of MAPK cascade|
|cytokine-mediated signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|apoptotic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.84|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDA2R Expression in NALM6 Cells: -0.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>