EDA2R

Gene Information

Official Symbol: EDA2R
Official Name: ectodysplasin A2 receptor
Aliases and Previous Symbols: N/A
Entrez ID: 60401
UniProt: Q9HAV5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016].
UniProt Summary: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11529
Expression level (log2 read counts): -0.64

Expression Distribution

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	1.84
Geldanamycin 0.01μM R05 exp235	2.34

ectodermal cell differentiation
tumor necrosis factor-activated receptor activity
ectoderm development
intrinsic apoptotic signaling pathway by p53 class mediator
tumor necrosis factor-mediated signaling pathway
signal transduction by p53 class mediator
positive regulation of JNK cascade
intrinsic apoptotic signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of JNK cascade
signaling receptor activity
regulation of stress-activated MAPK cascade
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of stress-activated protein kinase signaling cascade
cellular response to tumor necrosis factor
positive regulation of DNA-binding transcription factor activity
response to tumor necrosis factor
apoptotic signaling pathway
epidermis development
regulation of DNA-binding transcription factor activity
positive regulation of MAPK cascade
cytokine-mediated signaling pathway
regulation of cellular response to stress
regulation of MAPK cascade
apoptotic process
cellular response to cytokine stimulus
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
programmed cell death
positive regulation of phosphorylation
cell death
response to cytokine
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
integral component of plasma membrane
regulation of protein phosphorylation