EDEM3

Entrez Summary: N/A
UniProt Summary: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BVD-523 15μM R02 exp67	-1.75
Vinorelbine 0.001μM R05 exp249	1.9

PA
Glyco hydro 47

mannose trimming involved in glycoprotein ERAD pathway
protein deglycosylation involved in glycoprotein catabolic process
ubiquitin-dependent glycoprotein ERAD pathway
response to glycoprotein
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
protein demannosylation
protein alpha-1,2-demannosylation
glycoprotein catabolic process
endoplasmic reticulum quality control compartment
protein deglycosylation
ubiquitin-dependent ERAD pathway
ERAD pathway
response to unfolded protein
response to topologically incorrect protein
carbohydrate derivative catabolic process
response to endoplasmic reticulum stress
macromolecule glycosylation
protein glycosylation
glycosylation
endoplasmic reticulum lumen
glycoprotein biosynthetic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
glycoprotein metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
carbohydrate derivative biosynthetic process
protein catabolic process
calcium ion binding
cellular macromolecule catabolic process
response to organonitrogen compound
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
organonitrogen compound biosynthetic process