EDNRA [The Human Chemical-Genetic Interaction Map Project]

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======= EDNRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDNRA
  * **<color #00a2e8>Official Name</color>**: endothelin receptor type A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1909|1909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25101|P25101]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDNRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDNRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelin receptor activity|
|endothelin receptor signaling pathway|
|artery smooth muscle contraction|
|tonic smooth muscle contraction|
|enteric nervous system development|
|vascular smooth muscle contraction|
|phosphatidylinositol phospholipase C activity|
|branching involved in blood vessel morphogenesis|
|vasoconstriction|
|activation of phospholipase C activity|
|activation of adenylate cyclase activity|
|negative regulation of blood vessel diameter|
|respiratory gaseous exchange by respiratory system|
|positive regulation of phospholipase C activity|
|autonomic nervous system development|
|regulation of phospholipase C activity|
|smooth muscle contraction|
|positive regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|regulation of glucose transmembrane transport|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|neural crest cell differentiation|
|regulation of lipase activity|
|branching morphogenesis of an epithelial tube|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|vascular process in circulatory system|
|regulation of blood pressure|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|mesenchyme development|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|muscle contraction|
|positive regulation of cytosolic calcium ion concentration|
|muscle system process|
|epithelial tube morphogenesis|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|response to hypoxia|
|response to decreased oxygen levels|
|in utero embryonic development|
|response to oxygen levels|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|blood vessel development|
|divalent inorganic cation homeostasis|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|heart development|
|cell population proliferation|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|tissue morphogenesis|
|metal ion homeostasis|
|chordate embryonic development|
|cellular cation homeostasis|
|cellular ion homeostasis|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|embryo development|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|homeostatic process|
|cell development|
|tissue development|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.82|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13914
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDNRA Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>