EDNRA

Gene Information

Official Symbol: EDNRA
Official Name: endothelin receptor type A
Aliases and Previous Symbols: N/A
Entrez ID: 1909
UniProt: P25101
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13914
Expression level (log2 read counts): -3.8

Expression Distribution

Screen	Score
HMS-I2 5μM R06 exp287	-2.05
UMK57 1μM R01 exp59	-1.82
Temozolomide 200μM R04 exp189	2.11

endothelin receptor activity
endothelin receptor signaling pathway
artery smooth muscle contraction
tonic smooth muscle contraction
enteric nervous system development
vascular smooth muscle contraction
phosphatidylinositol phospholipase C activity
branching involved in blood vessel morphogenesis
vasoconstriction
activation of phospholipase C activity
activation of adenylate cyclase activity
negative regulation of blood vessel diameter
respiratory gaseous exchange by respiratory system
positive regulation of phospholipase C activity
autonomic nervous system development
regulation of phospholipase C activity
smooth muscle contraction
positive regulation of phospholipase activity
positive regulation of lipase activity
regulation of phospholipase activity
regulation of glucose transmembrane transport
neural crest cell development
stem cell development
mesenchymal cell development
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
neural crest cell differentiation
regulation of lipase activity
branching morphogenesis of an epithelial tube
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
mesenchymal cell differentiation
stem cell differentiation
morphogenesis of a branching epithelium
morphogenesis of a branching structure
vascular process in circulatory system
regulation of blood pressure
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
mesenchyme development
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger