EED [The Human Chemical-Genetic Interaction Map Project]

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======= EED =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EED
  * **<color #00a2e8>Official Name</color>**: embryonic ectoderm development
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8726|8726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75530|O75530]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EED&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EED|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of adaxial/abaxial pattern formation|
|histone methyltransferase activity (H3-K27 specific)|
|sex chromatin|
|pronucleus|
|positive regulation of histone H3-K27 methylation|
|histone H3-K27 methylation|
|histone methyltransferase activity|
|regulation of histone H3-K27 methylation|
|ESC/E(Z) complex|
|regulation of gene expression by genetic imprinting|
|genetic imprinting|
|nucleosome binding|
|negative regulation of G0 to G1 transition|
|positive regulation of histone methylation|
|regulation of G0 to G1 transition|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|regulation of histone methylation|
|chromatin organization involved in regulation of transcription|
|histone lysine methylation|
|negative regulation of gene expression, epigenetic|
|peptidyl-lysine methylation|
|positive regulation of histone modification|
|histone methylation|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|positive regulation of chromatin organization|
|spinal cord development|
|protein methylation|
|protein alkylation|
|regulation of histone modification|
|gene silencing|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|chromatin organization|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|central nervous system development|
|cellular response to cytokine stimulus|
|chromosome organization|
|identical protein binding|
|response to cytokine|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.15|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.01|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.92|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.73|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.73|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.82|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.82|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.95|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.42|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.56|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ezh2|EZH2]]|0.767|
|[[:human genes:s:suz12|SUZ12]]|0.688|
|[[:human genes:w:wdr24|WDR24]]|0.444|
|[[:human genes:p:pmm2|PMM2]]|0.433|
|[[:human genes:u:ube2g2|UBE2G2]]|0.413|
|[[:human genes:u:uhrf1|UHRF1]]|0.408|
|[[:human genes:s:smg9|SMG9]]|0.401|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2452
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EED Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>