EED

Gene Information

Official Symbol: EED
Official Name: embryonic ectoderm development
Aliases and Previous Symbols: N/A
Entrez ID: 8726
UniProt: O75530
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 1μM R01 exp46	-2.15
Oligomycin-A 2μM R00 exp25	-2.01
Bisphenol F 50μM R08 exp457	-1.92
Citral 50μM R06 exp274	-1.73
Nicotine 3000μM R08 exp510	-1.73
ML-792 0.2μM R08 exp505	1.82
VER-155008 3.9μM R06 exp301	1.82
Olaparib 4μM R08 exp512	1.85
Rucaparib 6.5μM R08 exp520	1.89
SNS-032 15μM R08 exp443	1.95
Bortezomib 0.05μM R00 exp7	2.42
Aminopterin 0.005μM R07 exp335	2.56
MLN-4924 0.2μM R00 exp21	3.83

Global Fraction of Cell Lines Where Essential: 7/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	1/14
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2452
Expression level (log2 read counts): 5.48

Expression Distribution

Gene	Correlation
EZH2	0.767
SUZ12	0.688
WDR24	0.444
PMM2	0.433
UBE2G2	0.413
UHRF1	0.408
SMG9	0.401
LAMTOR4	0.4

regulation of adaxial/abaxial pattern formation
histone methyltransferase activity (H3-K27 specific)
sex chromatin
pronucleus
positive regulation of histone H3-K27 methylation
histone H3-K27 methylation
histone methyltransferase activity
regulation of histone H3-K27 methylation
ESC/E(Z) complex
regulation of gene expression by genetic imprinting
genetic imprinting
nucleosome binding
negative regulation of G0 to G1 transition
positive regulation of histone methylation
regulation of G0 to G1 transition
chromatin silencing
chromatin organization involved in negative regulation of transcription
regulation of histone methylation
chromatin organization involved in regulation of transcription
histone lysine methylation
negative regulation of gene expression, epigenetic
peptidyl-lysine methylation
positive regulation of histone modification
histone methylation
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
positive regulation of chromatin organization
spinal cord development
protein methylation
protein alkylation
regulation of histone modification
gene silencing
positive regulation of chromosome organization
regulation of chromatin organization
regulation of gene expression, epigenetic
macromolecule methylation
methylation
peptidyl-lysine modification
negative regulation of cell cycle process
regulation of chromosome organization