SUZ12

Entrez Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].
UniProt Summary: Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.41
CB-5083 0.4μM R08 exp468	-2.26
Lead acetate 2000μM R08 exp498 no dilution day6	-2.18
L-74142 5μM R03 exp131	-1.97
CI-1040 9.5μM R08 exp472	-1.73
Pterostilbene 16μM R02 exp78	-1.72
ML-792 0.2μM R08 exp505	1.76
MLN-4924 2μM R00 exp22	1.98
R-DABN 8μM R03 exp111	2
VER-155008 3.9μM R06 exp301	2.13
SNS-032 15μM R08 exp443	2.54
Bortezomib 0.05μM R00 exp7	2.63
Aminopterin 0.005μM R07 exp335	2.85
MLN-4924 0.2μM R00 exp21	3.95

Global Fraction of Cell Lines Where Essential: 3/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RSC-type complex
histone methyltransferase activity (H3-K27 specific)
sex chromatin
histone methyltransferase activity
histone H3-K27 methylation
ESC/E(Z) complex
negative regulation of G0 to G1 transition
histone ubiquitination
regulation of G0 to G1 transition
protein-DNA complex
promoter-specific chromatin binding
methylated histone binding
chromatin DNA binding
histone lysine methylation
negative regulation of gene expression, epigenetic
peptidyl-lysine methylation
histone methylation
protein alkylation
protein methylation
regulation of gene expression, epigenetic
macromolecule methylation
nuclear body
methylation
peptidyl-lysine modification
negative regulation of cell cycle process
histone modification
covalent chromatin modification
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of cell cycle
protein ubiquitination
chromatin organization
negative regulation of cell differentiation
regulation of cell cycle process
protein modification by small protein conjugation
nucleolus
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
positive regulation of cell population proliferation
negative regulation of developmental process
protein modification by small protein conjugation or removal

Gene	Correlation
EED	0.688
EZH2	0.687