EEF1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= EEF1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF1A1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation elongation factor 1 alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1915|1915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68104|P68104]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. {ECO:0000269|PubMed:17177976}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU D3|
|GTP EFTU D2|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of D-erythro-sphingosine kinase activity|
|eukaryotic translation elongation factor 1 complex|
|cytoplasmic side of lysosomal membrane|
|regulation of chaperone-mediated autophagy|
|translation elongation factor activity|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|cortical actin cytoskeleton|
|tRNA binding|
|kinase binding|
|ruffle membrane|
|secretory granule lumen|
|translational elongation|
|ficolin-1-rich granule lumen|
|calmodulin binding|
|GTPase activity|
|regulation of autophagy|
|translation|
|regulation of protein catabolic process|
|GTP binding|
|peptide biosynthetic process|
|protein kinase binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|amide biosynthetic process|
|peptide metabolic process|
|response to growth factor|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|regulation of cellular catabolic process|
|nucleolus|
|regulation of kinase activity|
|leukocyte activation|
|regulation of transferase activity|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|cellular response to endogenous stimulus|
|RNA binding|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|regulation of phosphorylation|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 689/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|26/26|
|breast|28/33|
|central nervous system|53/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|67/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 716
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 12.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF1A1 Expression in NALM6 Cells: 12.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>