EEF1A1

Entrez Summary: N/A
UniProt Summary: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. {ECO:0000269|PubMed:17177976}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 689/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	28/33
central nervous system	53/56
cervix	3/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	19/20
lung	67/75
lymphocyte	15/16
ovary	25/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	4/5

Expression Distribution

Screen	Score
UMK57 0.6μM R03 exp107	2
Sucrose 20000μM R06 exp298	2.07

regulation of D-erythro-sphingosine kinase activity
eukaryotic translation elongation factor 1 complex
cytoplasmic side of lysosomal membrane
regulation of chaperone-mediated autophagy
translation elongation factor activity
cellular response to epidermal growth factor stimulus
response to epidermal growth factor
cortical actin cytoskeleton
tRNA binding
kinase binding
ruffle membrane
secretory granule lumen
translational elongation
ficolin-1-rich granule lumen
calmodulin binding
GTPase activity
regulation of autophagy
translation
regulation of protein catabolic process
GTP binding
peptide biosynthetic process
protein kinase binding
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
cellular response to growth factor stimulus
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
amide biosynthetic process
peptide metabolic process
response to growth factor
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
cellular amide metabolic process