EEFSEC [The Human Chemical-Genetic Interaction Map Project]

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======= EEFSEC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEFSEC
  * **<color #00a2e8>Official Name</color>**: eukaryotic elongation factor, selenocysteine-tRNA specific
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60678|60678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57772|P57772]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEFSEC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEFSEC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607695|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|GTP EFTU D2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|selenocysteine insertion sequence binding|
|selenocysteine incorporation|
|translational readthrough|
|translation elongation factor activity|
|ribonucleoprotein complex binding|
|tRNA binding|
|translational elongation|
|ribonucleoprotein complex|
|GTPase activity|
|regulation of translation|
|translation|
|GTP binding|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3.74|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.02|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.47|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.41|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.37|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.3|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.29|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-2.15|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.14|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.13|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.12|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.08|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.02|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.97|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.96|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.93|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.93|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.92|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.92|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.91|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.89|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.88|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.85|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.84|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.82|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.79|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.76|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.75|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.74|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.73|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.73|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.72|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.7|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.7|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.71|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.74|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.92|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.03|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sepsecs|SEPSECS]]|0.657|
|[[:human genes:p:pstk|PSTK]]|0.627|
|[[:human genes:s:sephs2|SEPHS2]]|0.55|
|[[:human genes:g:gpx4|GPX4]]|0.515|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 65/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|4/26|
|breast|1/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|6/20|
|lung|9/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEFSEC Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>