EEFSEC

Entrez Summary: N/A
UniProt Summary: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-3.74
Palbociclib 1μM R07 exp382	-3.02
ONC212 0.15μM R08 exp513	-2.97
Tubacin 1.6μM R07 exp416	-2.47
BI-2536 0.0042μM R03 exp95	-2.41
5-Fluorouracil 2μM R00 exp1	-2.37
JQ1 0.8μM R08 exp435	-2.3
Rotenone 2μM R00 exp33	-2.29
Nifurtimox 1μM R03 exp141	-2.15
Taxol 0.004μM R03 exp103	-2.14
OICR-9429 10μM R03 exp142	-2.13
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.12
Tenofovir 10μM R07 exp405	-2.08
Genistein 15μM R07 exp360	-2.02
Benzoate 10000μM R08 exp455	-1.97
Dimethyl-Sulfoxide 1pc R03 exp120	-1.96
Calcium Ionophore 0.4μM R07 exp342	-1.93
SGC2043 10μM R03 exp152	-1.93
I-BRD9 4μM R07 exp365	-1.92
JQ1 0.01μM R03 exp130	-1.92
Nocodazole 0.1μM R03 exp94	-1.91
UM0125461 0.74μM R02 exp84	-1.89
Isonicotinamide 500μM R03 exp129	-1.88
MKC9989 10μM R03 exp133	-1.85
Thimerosal 0.85μM R08 exp529	-1.84
Rapamycin 0.001μM R08 exp429	-1.82
Arsenate 40μM R06 exp264	-1.79
SB202190 10μM R03 exp148	-1.76
Chloramphenicol 2μM R00 exp12	-1.75
BH1 1μM R04 exp169	-1.74
Demecolcine 0.03μM R05 exp228	-1.73
UM131593 0.2μM R03 exp106	-1.73
CCCP 0.1μM R00 exp10	-1.72
PNU96415E 10μM R03 exp145	-1.7
SGC0946 7μM R03 exp151	-1.7
Deferoxamine 11μM R07 exp350	1.71
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.74
Cannabidiol 13μM R08 exp465	1.77
ZLN024 50μM R08 exp538	1.83
Cannabidiol 20μM R08 exp466	1.92
Pterostilbene 16μM R02 exp78	1.96
Centrinone 0.5μM R07 exp343	2.03
All-trans-Retinoic-Acid 40μM R07 exp334	2.09

Global Fraction of Cell Lines Where Essential: 65/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	4/26
breast	1/33
central nervous system	10/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	6/20
lung	9/75
lymphocyte	2/16
ovary	3/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	3/15
prostate	0/1
skin	1/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

GTP EFTU
GTP EFTU D2

selenocysteine insertion sequence binding
selenocysteine incorporation
translational readthrough
translation elongation factor activity
ribonucleoprotein complex binding
tRNA binding
translational elongation
ribonucleoprotein complex
GTPase activity
regulation of translation
translation
GTP binding
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression