EFHC1

Entrez Summary: This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].
UniProt Summary: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581). {ECO:0000269|PubMed:15258581, ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142, ECO:0000269|PubMed:28370826}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Clomiphene 4.4μM R02 exp68	-1.78
Metformin 40μM R03 exp132	-1.74

alpha-tubulin binding
cerebral cortex cell migration
telencephalon cell migration
forebrain cell migration
mitotic cytokinesis
mitotic spindle organization
mitotic spindle
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
cytoskeleton-dependent cytokinesis
cytokinesis
axoneme
microtubule cytoskeleton organization involved in mitosis
cerebral cortex development
spindle pole
spindle organization
regulation of cell division
pallium development
protein C-terminus binding
telencephalon development
neuronal cell body
forebrain development
microtubule cytoskeleton organization
centrosome
cell division
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
calcium ion binding
brain development
head development
cell migration
central nervous system development
cell cycle process
cell motility
localization of cell
cytoskeleton organization
locomotion
cell cycle
movement of cell or subcellular component