EFNB1 [The Human Chemical-Genetic Interaction Map Project]

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======= EFNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNB1
  * **<color #00a2e8>Official Name</color>**: ephrin B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1947|1947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98172|P98172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ephrin receptor binding|
|T cell costimulation|
|lymphocyte costimulation|
|neural crest cell migration|
|embryonic pattern specification|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|ephrin receptor signaling pathway|
|neural crest cell differentiation|
|positive regulation of T cell proliferation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of T cell proliferation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|ameboidal-type cell migration|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|mesenchyme development|
|regulation of leukocyte proliferation|
|membrane raft|
|positive regulation of cell-cell adhesion|
|axon guidance|
|neuron projection guidance|
|synapse|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|axonogenesis|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|axon development|
|positive regulation of cell activation|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of leukocyte activation|
|regulation of cell activation|
|neuron projection development|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|neuron differentiation|
|cell motility|
|localization of cell|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.92|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.77|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.7|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNB1 Expression in NALM6 Cells: 3.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>