EFNB1

Entrez Summary: The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	-1.92
Mdivi-1 15μM R05 exp217	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	-1.73
CI-1040 9.5μM R08 exp472	1.7
BI-6727 0.001μM R01 exp42	1.91

Global Fraction of Cell Lines Where Essential: 1/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

ephrin receptor binding
T cell costimulation
lymphocyte costimulation
neural crest cell migration
embryonic pattern specification
neural crest cell development
mesenchymal cell development
stem cell development
ephrin receptor signaling pathway
neural crest cell differentiation
positive regulation of T cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
regulation of T cell proliferation
mesenchymal cell differentiation
stem cell differentiation
ameboidal-type cell migration
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
mesenchyme development
regulation of leukocyte proliferation
membrane raft
positive regulation of cell-cell adhesion
axon guidance
neuron projection guidance
synapse
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
positive regulation of lymphocyte activation
axonogenesis
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
axon development
positive regulation of cell activation
cell morphogenesis involved in neuron differentiation
pattern specification process