EFNB2 [The Human Chemical-Genetic Interaction Map Project]

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======= EFNB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNB2
  * **<color #00a2e8>Official Name</color>**: ephrin B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1948|1948]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52799|P52799]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600527|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of aorta morphogenesis|
|positive regulation of aorta morphogenesis|
|regulation of artery morphogenesis|
|positive regulation of artery morphogenesis|
|venous blood vessel morphogenesis|
|regulation of postsynaptic neurotransmitter receptor internalization|
|nephric duct morphogenesis|
|negative regulation of keratinocyte proliferation|
|venous blood vessel development|
|nephric duct development|
|presynapse assembly|
|positive regulation of cardiac muscle cell differentiation|
|cell migration involved in sprouting angiogenesis|
|presynapse organization|
|lymph vessel development|
|ephrin receptor binding|
|positive regulation of cardiocyte differentiation|
|blood vessel endothelial cell migration|
|regulation of keratinocyte proliferation|
|regulation of cardiac muscle cell differentiation|
|positive regulation of cardiac muscle tissue development|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|regulation of cardiocyte differentiation|
|integral component of postsynaptic density membrane|
|regulation of receptor internalization|
|T cell costimulation|
|lymphocyte costimulation|
|sprouting angiogenesis|
|integral component of presynaptic membrane|
|positive regulation of striated muscle cell differentiation|
|endothelial cell migration|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|virus receptor activity|
|regulation of cardiac muscle tissue development|
|Schaffer collateral - CA1 synapse|
|epithelial cell migration|
|ephrin receptor signaling pathway|
|epithelium migration|
|positive regulation of muscle cell differentiation|
|positive regulation of neuron death|
|tissue migration|
|synapse assembly|
|viral entry into host cell|
|regulation of receptor-mediated endocytosis|
|regulation of striated muscle cell differentiation|
|entry into host|
|entry into host cell|
|negative regulation of epithelial cell proliferation|
|kidney epithelium development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of muscle cell differentiation|
|negative regulation of neuron projection development|
|interaction with host|
|ameboidal-type cell migration|
|negative regulation of cell projection organization|
|positive regulation of vasculature development|
|viral life cycle|
|positive regulation of T cell activation|
|regulation of endocytosis|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|negative regulation of neuron differentiation|
|positive regulation of cell-cell adhesion|
|axon guidance|
|neuron projection guidance|
|kidney development|
|synapse organization|
|renal system development|
|negative regulation of neurogenesis|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|regulation of T cell activation|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|glutamatergic synapse|
|positive regulation of lymphocyte activation|
|axonogenesis|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|axon development|
|focal adhesion|
|positive regulation of cell activation|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|cardiovascular system development|
|regulation of cellular protein localization|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|symbiotic process|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14879
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNB2 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>